Etiology of inflammatory bowel disease: new insights

Gabriela Fonseca-Camarillo, Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Ciudad de México, México

This article reviews current knowledge about the main areas of research in regards the role of genetic, immunological, and environmental factors implicated in the onset and exacerbation of inflammatory bowel disease (IBD). Over the past decade, there has been enormous progress in the discovery of numerous genetic variants that increase or decrease the risk of IBD.

Palabras clave: Ulcerative Colitis. Crohn Disease. Genetic Factors. Diet. Mucosal Microbiota. Dysbiosis.